Thermo Fisher Scientific NLRP3 Recombinant Rabbit Monoclonal Antibody (SC06-23)
NLRP3 단백질을 인식하는 재조합 토끼 단클론 항체. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 적합. 높은 특이성과 일관된 로트 간 재현성 제공. Human, Mouse, Rat 시료 반응성. 단백질 A 정제, 1 mg/mL 농도.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 4 publications |
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | View 2 publications |
| Flow Cytometry (Flow) | 1:50–1:100 | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Rabbit, Rat |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SC06-23 |
| Immunogen | Recombinant protein within Human NLRP3 (aa 5–161) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809541 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select optimal candidates.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
The NLRP3 gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif.
This protein interacts with PYCARD/ASC, a caspase recruitment domain-containing protein, forming part of the NALP3 inflammasome complex.
Functions include:
- Activation of NF-kappaB signaling
- Regulation of inflammation, immune response, and apoptosis
Mutations are associated with:
- Familial cold autoinflammatory syndrome
- Neonatal-onset multisystem inflammatory disease
Multiple alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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