Thermo Fisher Scientific COX1 Recombinant Rabbit Monoclonal Antibody (SC68-05)
COX1 단백질을 표적하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, Flow Cytometry에 사용 가능. 높은 특이성과 재현성을 제공하며, HEK293 세포에서 발현된 IgG 형식의 항체. 단백질 A로 정제되어 안정적인 결과 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SC68-05 |
| Immunogen | Synthetic peptide within Human COX1 (aa 116–159) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809545 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened for optimal production. Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to large rabbit immune repertoire
Target Information
PTGS1 (COX1, Cyclooxygenase 1) is a key enzyme in prostaglandin biosynthesis, functioning as both a dioxygenase and a peroxidase. Two isozymes exist: constitutive PTGS1 and inducible PTGS2, differing in regulation and tissue distribution. PTGS1 regulates angiogenesis in endothelial cells and is inhibited by NSAIDs such as aspirin. It is involved in cell-cell signaling and tissue homeostasis. Alternative splicing generates two transcript variants regulated by cytokines and growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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