Thermo Fisher Scientific VEGF Monoclonal Antibody (OTI2F7), TrueMAB

Thermo Fisher Scientific VEGF Monoclonal Antibody (OTI2F7), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution

• 1:1,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

VEGF (vascular endothelial growth factor) is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis, promoting tumor progression and metastasis.
It enhances endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability.
The VEGF family includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF.
VEGF and its receptors (VEGFR-1/flt-1 and VEGFR-2/flk-1/KDR) are key regulators of angiogenesis and embryonic vascular development.
A soluble form of FLT1 (sFLT1) binds VEGF with high affinity, acting as an inhibitor of angiogenesis.
Elevated VEGF levels are associated with POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes), also known as Crow-Fukase syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.