Thermo Fisher Scientific L1CAM Monoclonal Antibody (OTI10C12), TrueMAB
인간 L1CAM 단백질을 인식하는 Mouse IgG1 단클론 항체로 다양한 응용(WB, IHC, Flow, IP)에 적합. 고순도 친화 크로마토그래피 정제, 동결건조 형태로 제공. 신경계 발달 관련 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | 2–4 µg/mg |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10C12 |
| Immunogen | Full-length human recombinant protein of L1CAM produced in HEK293T cells (CD171, UniProt ID: P32004-1, antigen range 1–1257) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
L1CAM/CD171 is an axonal glycoprotein of the immunoglobulin superfamily. Its ectodomain contains immunoglobulin-like and fibronectin type III domains linked to a conserved cytoplasmic region via a transmembrane sequence.
This molecule is essential for nervous system development, including neuronal migration and differentiation.
Mutations in the L1CAM gene cause X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus).
Alternative splicing of a neuron-specific exon is considered functionally significant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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