Thermo Fisher Scientific GAD1 Monoclonal Antibody (OTI5D8), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

GAD-65 and GAD-67 are members of the group II decarboxylase family that catalyze the conversion of L-glutamic acid to GABA (gamma-aminobutyric acid).

• GAD-65: Localized to synaptic vesicle membranes, activated during increased neurotransmission demand.
• GAD-67: Distributed throughout the cell, responsible for basal GABA synthesis.
  Loss of GAD-65 impairs GABA neurotransmission, while loss of GAD-67 is lethal.
  Two isoforms exist for GAD-67 due to alternative splicing: the predominant GAD-67 and the minor GAD-25.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.