Thermo Fisher Scientific Glucocorticoid Receptor Recombinant Rabbit Monoclonal Antibody (2D8)

Thermo Fisher Scientific Glucocorticoid Receptor Recombinant Rabbit Monoclonal Antibody (2D8)

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:5,000
• Flow Cytometry (Flow): 1:20–1:200

Product Specifications

Product Specific Information

This antibody has been tested in direct-ELISA.

Target Information

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that functions as both a transcription factor and a regulator of other transcription factors. It forms heteromeric cytoplasmic complexes with heat shock factors and immunophilins and translocates to the nucleus upon ligand binding.
This receptor is expressed throughout the heart, including atria, ventricles, aorta, apex, septum, and atrioventricular node, in both adult and fetal tissues.
Multiple transcript variants and isoforms exist due to alternative splicing and promoter usage. Mutations in NR3C1 cause glucocorticoid resistance. GR binds steroids such as dexamethasone with nanomolar affinity and requires chaperone protein complexes for ligand activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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