Thermo Fisher Scientific Glucocorticoid Receptor Recombinant Rabbit Monoclonal Antibody (2D8)
Glucocorticoid Receptor를 인식하는 recombinant rabbit monoclonal antibody로, Western blot 및 Flow cytometry에 적합합니다. 높은 특이성과 재현성을 제공하며, HEK293 발현 시스템에서 생산되었습니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Glucocorticoid Receptor Recombinant Rabbit Monoclonal Antibody (2D8)
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:5,000
- Flow Cytometry (Flow): 1:20–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2D8 |
| Immunogen | A synthesized peptide derived from human GR (Glucocorticoid Receptor, NR3C1, UniProt ID: P04150-1, antigen range: 2–149) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898325 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that functions as both a transcription factor and a regulator of other transcription factors. It forms heteromeric cytoplasmic complexes with heat shock factors and immunophilins and translocates to the nucleus upon ligand binding.
This receptor is expressed throughout the heart, including atria, ventricles, aorta, apex, septum, and atrioventricular node, in both adult and fetal tissues.
Multiple transcript variants and isoforms exist due to alternative splicing and promoter usage. Mutations in NR3C1 cause glucocorticoid resistance. GR binds steroids such as dexamethasone with nanomolar affinity and requires chaperone protein complexes for ligand activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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