Thermo Fisher Scientific CD27 Recombinant Rabbit Monoclonal Antibody (4A1)

Applications

• Western Blot (WB): 1:500–1:5,000
• Direct ELISA (tested)

Product Specifications

Product Specific Information

This antibody has been tested in direct ELISA.

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. Members of this family regulate cell proliferation and death. Unlike other TNFR/TNF family members, CD27 and its ligand CD70 are mainly expressed in lymphocytes.
High expression of CD27 depends on antigen receptor ligation, while CD70 expression requires additional co-stimulatory or pro-inflammatory signals. CD27 exists as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells, and a subset of B cells.
Activation of T cells via the TCR-CD3 complex increases CD27 expression and releases soluble CD27 (sCD27, 28–32 kDa) into plasma, urine, or spinal fluid. Soluble CD27 serves as an important prognostic marker for acute and chronic B cell malignancies.
RgpA, a cysteine proteinase, degrades CD27 and counteracts T cell activation mediated by CD27-CD70 interaction. CD27-binding protein (SIVA) is a proapoptotic protein that binds to CD27 and plays a role in receptor-induced apoptosis.
Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지