Thermo Fisher Scientific CDK4 Recombinant Rabbit Monoclonal Antibody (8F2)
CDK4 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 Immunoprecipitation에 적합. 높은 특이성과 재현성을 제공하며, HEK293 세포에서 발현된 IgG 형식. 세포주기 조절 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:5,000
Immunoprecipitation (IP)
- Tested Dilution: 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8F2 |
| Immunogen | A synthesized peptide derived from human CDK4 (UniProt ID: P11802-1, antigen range: 290–303) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898328 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
CDK4/cyclin D3 serine/threonine kinase is a dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and plays a key role in the control of cell proliferation during the G1 phase of the cell cycle.
CDK4 forms a complex with D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). It mediates phosphorylation of the C-terminal region of Rb protein, leading to transcriptional repression of the E2F complex.
CDC37 and HSP90 preferentially associate with CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of CDK4 and CDK2. CDK6 and CDK4 both phosphorylate Rb protein but differ in residue selectivity: CDK6 targets Thr821, while CDK4 targets Thr826.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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