Thermo Fisher Scientific DNMT3B Recombinant Rabbit Monoclonal Antibody (SY09-07)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

CpG methylation is an epigenetic modification crucial for embryonic development, imprinting, and X-chromosome inactivation. DNA methylation is required for mammalian development.
This gene encodes a DNA methyltransferase functioning in de novo methylation, primarily localizing to the nucleus with developmentally regulated expression.
Mutations in DNMT3B cause ICF syndrome (Immunodeficiency-Centromeric instability-Facial anomalies).
Six alternatively spliced transcript variants have been described; full-length sequences of variants 4 and 5 have not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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