Thermo Fisher Scientific ATM Recombinant Rabbit Monoclonal Antibody (SI70-01)
인간 ATM 단백질을 표적으로 하는 재조합 토끼 모노클로날 항체로 높은 특이성과 감도를 제공합니다. WB, IHC, ICC 등 다양한 응용에 적합하며, 로트 간 일관성과 동물 유래 성분이 없는 포뮬레이션을 제공합니다. 연구용으로 DNA 손상 복구 및 세포주기 조절 연구에 활용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SI70-01 |
| Immunogen | Synthetic peptide within Human ATM aa 1,951–2,000 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809357 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to large rabbit immune repertoire
Target Information
Ataxia-telangiectasia Mutated (ATM) is a member of the PI3/PI4 kinase family. It is involved in DNA damage response and cell cycle regulation. The ATM gene encodes a protein that phosphorylates downstream targets such as P53, Mdm2, BRCA1, and SMC1, playing a crucial role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens.
ATM activation leads to a kinase cascade regulating apoptosis and DNA damage repair. Defects in ATM are associated with hypersensitivity to ionizing radiation and impaired p53 induction, contributing to neurological degeneration and increased cancer risk.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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