Thermo Fisher Scientific CDK1 Recombinant Rabbit Monoclonal Antibody (SM01-44)
CDK1 단백질을 인식하는 재조합 토끼 단클론 항체로 높은 특이성과 민감도를 제공. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. HEK293 세포 발현 시스템 기반, lot-to-lot 일관성과 동물 유래 성분 없음. 연구용으로만 사용 가능.
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Thermo Fisher Scientific CDK1 Recombinant Rabbit Monoclonal Antibody (SM01-44)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SM01-44 |
| Immunogen | Synthetic peptide within Human CDK1 aa 228–277 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809349 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to large rabbit immune repertoire
Target Information
CDK1 (Cell Division Control protein 1) is essential for the completion of START, the controlling event in the cell cycle required to initiate mitosis.
It acts as the catalytic subunit of the M-Phase Promoting Factor complex that induces mitosis and is conserved among eukaryotes.
CDK1 mediates phosphorylation of Bcl-2 during G2/M phase arrest after photodynamic therapy with hypericin, delaying apoptosis.
CDK inhibitors such as NU2058 have shown therapeutic potential in androgen-independent prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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