Thermo Fisher Scientific PABP4 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.

Target Information

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3′ ends of most eukaryotic mRNAs.
PABPC4 (inducible PABP) is an activation-induced T-cell mRNA encoding a protein whose levels increase approximately fivefold upon T-cell activation.
It contains four RNA-binding domains and a proline-rich C terminus, and is primarily localized in the cytoplasm.
PABPC4 may regulate the stability of labile mRNA species in activated T cells and is also expressed as APP1 (activated-platelet protein-1) on thrombin-activated rabbit platelets.
It may participate in protein translation regulation in platelets and megakaryocytes or in polyadenylate binding/stabilization in platelet dense granules.
Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.