Thermo Fisher Scientific PABP4 Polyclonal Antibody
PABP4 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, IP 등 다양한 실험에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 인간 및 생쥐에 반응. 액상 형태로 4°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 525 and 575 of human Poly(A)-binding protein 4 (PABPC4, UniProt ID: Q13310-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3′ ends of most eukaryotic mRNAs.
PABPC4 (inducible PABP) is an activation-induced T-cell mRNA encoding a protein. Activation of T cells increases PABPC4 mRNA levels approximately 5-fold.
PABPC4 contains four RNA-binding domains and a proline-rich C terminus, and is mainly localized in the cytoplasm. It may regulate the stability of labile mRNA species in activated T cells.
PABPC4 is also known as APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets, and may be involved in protein translation regulation in platelets and megakaryocytes or in polyadenylate stabilization in platelet dense granules.
Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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