Thermo Fisher Scientific Phospho-Cofilin (Ser3) Monoclonal Antibody (G.577.4)
Phospho-Cofilin (Ser3) 단백질의 인산화 상태를 검출하는 토끼 단클론 항체. Western blot 및 Immunocytochemistry에 적합하며, 다양한 종에 반응. 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | G.577.4 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer3 of human cofilin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 42 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_11000491 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. It regulates actin cytoskeleton dynamics and is essential for normal mitosis and cytokinesis. Cofilin plays a key role in cell morphology and cytoskeletal organization, and is required for the up-regulation of atypical chemokine receptor ACKR2, enhancing chemokine uptake and degradation. It is also necessary for neural tube morphogenesis and neural crest cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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