Thermo Fisher Scientific TRAF1 Monoclonal Antibody (K.915.10)
TRAF1 단백질을 인식하는 Rabbit monoclonal antibody (Clone K.915.10). Western blot, IHC, ICC/IF, Flow cytometry, IP 등 다양한 응용에 적합. Human 시료 반응성, 고순도 친화 크로마토그래피 정제, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1600 | - |
| Immunocytochemistry (ICC/IF) | 1:800 | - |
| Flow Cytometry (Flow) | 1:200 | - |
| Immunoprecipitation (IP) | 1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K.915.10 |
| Immunogen | Synthetic peptide corresponding to residues surrounding cysteine 57 of human TRAF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 25 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10979261 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The protein encoded by this gene is a member of the TNF receptor (TNFR)-associated factor (TRAF) protein family. TRAF proteins mediate signal transduction from various receptors of the TNFR superfamily.
TRAF1 and TRAF2 form a heterodimeric complex required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB.
The TRAF1-TRAF2 complex interacts with inhibitor-of-apoptosis proteins (IAPs), mediating anti-apoptotic signals from TNF receptors.
Expression of TRAF1 can be induced by Epstein-Barr virus (EBV). EBV membrane protein 1 (LMP1) interacts with TRAF proteins, linking LMP1-mediated B lymphocyte transformation to TNFR signaling.
Three transcript variants encoding two different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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