Thermo Fisher Scientific Phospho-Aurora A (Thr288) Monoclonal Antibody (F.131.2)
Aurora A (Thr288) 인산화 형태를 특이적으로 인식하는 단클론 항체로, 인간 시료에 반응합니다. Western blot 및 ICC/IF에 적합하며, 고순도 친화 크로마토그래피 정제. 세포 분열 및 암 연구용으로 최적화된 연구용 항체.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: View 2 publications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:1,600
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F.131.2 |
| Immunogen | Synthetic phosphopeptide corresponding to residues around pThr288 of human Aurora A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 334 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10983549 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, particularly in the centrosome/spindle pole region during chromosome segregation.
Aurora A is a key factor in tumor development and progression, and is overexpressed in human cancers such as breast, ovarian, and colorectal. It is considered a potential target for anticancer drug treatment.
Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus, and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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