Thermo Fisher Scientific Tetanus Toxic Fragment C Polyclonal Antibody
테타누스 톡신 C-프래그먼트에 특이적인 토끼 폴리클로날 항체로, Western blot, ELISA, IP에 사용 가능. 높은 농도(68 mg/mL)의 액상 형태로 제공되며, -20°C 보관 권장. 연구용으로만 사용.
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Thermo Fisher Scientific Tetanus Toxic Fragment C Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:40,000 |
| ELISA | 1:50,000–1:250,000 |
| Immunoprecipitation (IP) | 1:1,000–1:40,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bacteria |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Prepared from whole rabbit serum produced by repeated immunizations with a polyhistidine-tagged TTFC fusion protein expressed in E. coli corresponding to full length TTFC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 68 mg/mL |
| Storage Buffer | 0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is directed against the C fragment of Tetanus toxin derived from Clostridium tetani. A BLAST analysis suggests cross-reactivity with Clostridium tetani. Cross-reactivity with TTFC from other sources has not been determined.
Target Information
Tetanus toxin C-fragment (TTc) is a non-toxic 52 kDa polypeptide generated by papain cleavage of tetanus toxin, corresponding to the C-terminal 451 amino acids.
Tetanus is caused by a neurotoxin produced by the anaerobic bacterium Clostridium tetani, commonly found in soil, feces, and on objects such as rusty metal. Puncture wounds are a common cause of infection.
The toxin acts on presynaptic membranes of both central and peripheral nervous systems to block neurotransmitter release. In its toxic form, tetanus neurotoxin is a 150 kDa protein consisting of a light chain and a heavy chain.
- Light chain: enzymatic portion responsible for toxic effects
- Heavy chain: binds to neuron and aids delivery of light chain
A single disulfide bond links the two chains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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