Thermo Fisher Scientific CaM Kinase IV Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at 4°C prior to restoration.
• For extended storage, aliquot contents and freeze at -20°C or below.
• Avoid cycles of freezing and thawing.
• Centrifuge if solution is not clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

This antiserum is directed against human CaM Kinase IV protein.
BLAST analysis suggests reactivity with human, mouse, and rat proteins based on 100% homology for the immunogen sequence.
Cross-reactivity with CaM Kinase IV homologues from other sources has not been determined.

Target Information

CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.
The nuclear localization of CaMKIV aligns with its role in calcium-dependent gene expression.
CaMKIV is abundant in testis, T-cells, and neurons, and contributes to synaptic plasticity and calcium signaling affecting NFAT transcription regulation.
In testes, CaMKIV is expressed in germ cells and associated with chromatin, suggesting a role in chromatin remodeling during spermatid nuclear condensation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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