Thermo Fisher Scientific Cyclin T2 Polyclonal Antibody
Cyclin T2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ELISA, IP에 사용 가능. Human 반응성, Unconjugated 형태의 고농도(85 mg/mL) 액상 시약이며, -20°C에서 보관. 연구용으로 CDK9 관련 전사 조절 연구에 적합.
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- 100-401-931
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:5,000–1:20,000 |
| Immunoprecipitation (IP) | 1:500–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to amino acids 1–584 of human Cyclin T2a protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 85 mg/mL |
| Storage Buffer | Whole serum |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid repeated freeze/thaw cycles. Centrifuge if not clear after standing at room temperature. Stable for several weeks at 4°C as undiluted liquid. Dilute only prior to immediate use.
This antibody specifically reacts with human Cyclin T2 proteins (74 and 81 kDa isoforms) by western blot. Protein BLAST analysis suggests cross-reactivity with Cyclin T2a and T2b from dog (96%), bovine (93%), mouse (88%), and rat (85%) based on high sequence homology. Reactivity with homologues from other species is unknown.
Target Information
Cyclin T2 belongs to the conserved cyclin family, characterized by periodic protein abundance through the cell cycle. Cyclins regulate CDK kinases and exhibit distinct expression and degradation patterns, coordinating mitotic events. Cyclin T2 and CDK9 form subunits of the transcription elongation factor p-TEFb, which interacts with and negatively regulates HIV-1 Tat protein. A pseudogene is located on chromosome 1. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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