Thermo Fisher Scientific ALK Monoclonal Antibody (OTI3E4), TrueMAB
인간 ALK 단백질을 인식하는 Mouse 단일클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태이며 PBS 완충액에 8% 트레할로스 포함. 뇌 발달 관련 연구 및 ALK 변이 종양 연구에 활용 가능합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3E4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors, including:
- Anaplastic large cell lymphoma
- Neuroblastoma
- Non-small cell lung cancer
Chromosomal rearrangements commonly create a fusion gene between ALK (chromosome 2) and NPM (chromosome 5). The resulting NPM-ALK fusion protein is oncogenic.
ALK encodes a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, showing high sequence similarity to LTK. It plays a critical role in neuronal development and signaling.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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