Thermo Fisher Scientific CIITA Polyclonal Antibody
CIITA 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 사용 가능하며, 인간·마우스·랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태로, 1 mg/mL 농도 및 PBS 버퍼에 0.02% sodium azide 포함.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 10 µg/mL
- Publications: 1 publication available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near the amino terminus of human CIITA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C (up to 3 months), −20°C (long-term) |
| Shipping Conditions | Ambient (domestic), Wet ice (international) |
| RRID | AB_11154145 |
Product Specific Information
- Suggested positive control: rat brain tissue lysate
- PA5-21031 can be used with blocking peptide PEP-1145
Target Information
CIITA contains an acidic transcriptional activation domain, four leucine-rich repeats (LRRs), and a GTP binding domain. It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex (MHC II) gene transcription, functioning as the "master control factor" for these genes.
CIITA binds GTP to facilitate nuclear transport and uses intrinsic acetyltransferase (AT) activity to act as a coactivator.
Mutations in CIITA are associated with bare lymphocyte syndrome type II, rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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