Thermo Fisher Scientific NPC1 Polyclonal Antibody
NPC1 단백질을 검출하기 위한 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF, IP, IM 등 다양한 응용에 적합합니다. 인간, 생쥐 등 여러 종에 반응하며, 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:250 |
| Immunoprecipitation (IP) | 1:10–1:500 |
| Immunomicroscopy (IM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Non-human primate, Pig, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal region of human NPC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2298492 |
Product Specific Information
By Western blot, PA1-16817 detects heterogeneously glycosylated NPC1 protein with prominent bands at approximately 170 and 220 kDa.
Suggested positive control: Human fibroblast cell lysate.
Target Information
Mutations in the Niemann-Pick disease type C1 (NPC1) gene cause a fatal progressive neurodegenerative disorder characterized by abnormal lipid sequestration, including cholesterol and glycosphingolipids.
The NPC1 protein is a large membrane protein located in endosomes and lysosomes, mediating intracellular cholesterol trafficking by binding cholesterol at its N-terminal domain.
NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments for hydrolysis and cholesterol release.
Recent studies have identified NPC1, along with FTO, MC4R, and PTER, as a risk locus for early-onset and morbid adult obesity in European populations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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