Thermo Fisher Scientific CD204 Polyclonal Antibody
CD204 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, 인간 및 비인간 영장류 시료에 반응합니다. Western blot과 면역세포염색에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to an internal portion of human Macrophage Scavenger Receptor I (between residues 300–350). [UniProt P21757] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.97 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2298117 |
Product Specific Information
Suggested positive control: antigen standard for MSR1 (transient overexpression lysate), mouse liver lysate, mouse liver protein.
Target Information
The CD204 gene encodes class A macrophage scavenger receptors, which include three isoforms (1, 2, 3) generated by alternative splicing. These macrophage-specific trimeric integral membrane glycoproteins are involved in various macrophage-associated physiological and pathological processes such as atherosclerosis, Alzheimer’s disease, and host defense.
- Isoforms 1 and 2 mediate endocytosis of modified low-density lipoproteins (LDLs).
- Isoform 3 does not internalize modified LDL due to altered intracellular processing, remaining trapped within the endoplasmic reticulum.
- Isoform 3 can inhibit the function of isoforms 1 and 2 when co-expressed, suggesting a dominant negative regulatory mechanism.
Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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