Thermo Fisher Scientific GABBR1 Monoclonal Antibody (N93A/49), FITC
GABBR1 단백질을 인식하는 FITC 결합 단클론 항체로, Western blot 및 면역세포염색에 사용 가능. 사람, 마우스, 랫트 반응성. 단백질 G 정제 및 보존제 무첨가. 4°C 암조건 보관.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:1,000 | |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N93A/49 |
| Immunogen | Fusion protein amino acids 873–977 (cytoplasmic C-terminus) of rat GABA(B)R1 |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.09 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931991 |
Additional Formats
- Unconjugated (MA5-27704)
- APC (MA5-45536)
- PE (MA5-45539)
- PerCP (MA5-45538)
- Custom conjugation available upon request
Product Specific Information
- 1 µg/mL of MA5-45537 was sufficient for detection of GABA(B)R1 in 20 µg of rat brain membrane lysate using colorimetric immunoblot analysis with goat anti-mouse IgG:HRP as secondary antibody.
- Detects approximately 115 kDa.
- No cross-reactivity against GABA(B)R2.
- This antibody was formerly sold as clone S93A-49.
Target Information
GABA(B) receptor 1 (GABBR1) acts as a receptor for gamma-aminobutyric acid (GABA). Its activity is mediated by G-proteins that inhibit adenylyl cyclase, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium channels, and modulate inositol phospholipid hydrolysis.
It plays a key role in inhibitory synaptic transmission, regulating neurotransmitter release and neuronal excitability. GABBR1 is involved in synaptic inhibition, hippocampal long-term potentiation, slow-wave sleep, muscle relaxation, and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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