Thermo Fisher Scientific NMDAR2B Monoclonal Antibody (S59), PerCP
NMDAR2B 단백질을 인식하는 S59 클론 단일클론 항체로, PerCP 형광 표지되어 있습니다. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능하며 인간, 마우스, 랫트 반응성을 가집니다. 단백질 G 정제, 보존제 없음, 4°C 보관.
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Thermo Fisher Scientific NMDAR2B Monoclonal Antibody (S59), PerCP
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S59 |
| Immunogen | Fusion protein amino acids 20–271 (extracellular N-terminus) of rat NR2B |
| Conjugate | PerCP |
| Excitation / Emission Max | 482 / 675 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931918 |
Additional Formats
Product Specific Information
- 1 µg/mL of MA5-45464 detects NR2B in 10 µg of rat brain lysate by colorimetric immunoblot using goat anti-mouse IgG:HRP as secondary antibody.
- Detects approximately 166 kDa.
- No cross-reactivity against NR2A.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. These receptors are involved in long-term potentiation, a mechanism underlying memory and learning. NMDAR2B plays a role in neuronal development and is implicated in neurological disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death. Overexpression of NR2B enhances learning and memory, while reduced expression is associated with cognitive decline. Phosphorylation at Tyr1472 may increase synaptic NMDAR expression, contributing to synaptic plasticity. Dysfunction of NMDAR2B is linked to epileptic encephalopathy and mental retardation.
Regulatory Information
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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