
Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI3C8), TrueMAB
ABCB1 단백질을 인식하는 마우스 단클론 항체로, IHC(P)에서 1:150 희석으로 사용 가능. 인간 시료에 반응하며, 동결건조 형태로 제공. 멀티드럭 내성 연구 및 세포막 수송 단백질 분석에 적합. -20°C 보관 권장.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC(P)]: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The membrane-associated protein encoded by the ABCB1 gene belongs to the ATP-binding cassette (ABC) transporter superfamily. These transporters move various molecules across cellular membranes.
ABCB1 is part of the MDR/TAP subfamily, which is involved in multidrug resistance. The encoded protein functions as an ATP-dependent drug efflux pump, reducing intracellular drug accumulation and contributing to resistance against anticancer agents. It also acts as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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