Thermo Fisher Scientific Phospho-Tau (Ser416) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody is predicted to react with bovine, canine, human, mouse, and non-human primate based on 100% sequence homology.
Specific for ~59, 65, 68k Tau isoforms phosphorylated at Ser^416 in western blots of rat brain extracts.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both.
Axonal polarity is predetermined by TAU/MAPT localization within the neuronal cell body domain defined by the centrosome.
Short isoforms allow cytoskeletal plasticity, while longer isoforms contribute to stabilization.
In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease brain.
Hyper-phosphorylation impairs Tau’s microtubule binding, leading to destabilization and neuronal degeneration.
Tau is phosphorylated by several kinases including GSK-3β, PKA, cdk5, and casein kinase II.
Hyper-phosphorylated Tau is found in neurofibrillary lesions in Alzheimer’s disease and other CNS disorders such as Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.