Thermo Fisher Scientific GABRB2 Polyclonal Antibody
Thermo Fisher Scientific의 GABRB2 Polyclonal Antibody는 mouse와 rat에서 반응하는 rabbit IgG 항체로, Western blot에 적합합니다. Rat GABRB2 beta 2 subunit의 cytoplasmic loop로부터 유래된 fusion protein을 면역원으로 사용하며, 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein from the cytoplasmic loop of the beta 2 subunit of rat GABRB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2278880 |
Product Specific Information
This antibody is predicted to react with canine, human, mouse, and non-human primate based on 100% sequence homology.
Target Information
GAD-65 and GAD-67, glutamate decarboxylases, catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system, GABA acts as the main inhibitory neurotransmitter by increasing Cl⁻ conductance that inhibits neuronal firing.
GABA activates ionotropic (GABAA) and metabotropic (GABAB) receptors, and a third class called GABAC.
- GABAA and GABAC receptors: Ligand-gated ion channels, structurally and functionally distinct.
- GABAA receptor family members: GABAA Rα1–6, GABAA Rβ1–3, GABAA Rγ1–3, GABAA Rδ, GABAA Rε, GABAA Rρ1, GABAA Rρ2.
- GABAB receptor family: GABAB R1α and GABAB R1β.
- GABA transporters: GABA T-1, T-2, T-3 (also designated GAT-1, -2, -3), terminate GABA action.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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