Thermo Fisher Scientific Phospho-GABBR1 (Ser923) Polyclonal Antibody
GABBR1 단백질의 Ser923 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며, Mouse 및 Rat 시료에 반응. 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
- Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser923 of rat GABBR1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2247368 |
Product Specific Information
This antibody is predicted to react with bovine, human, mouse, and non-human primate based on 100% sequence homology.
It detects a band at approximately 102 kDa, representing GABAB R1 protein phosphorylated at Ser923.
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that:
- Inhibit adenylyl cyclase activity
- Stimulate phospholipase A2
- Activate potassium channels
- Inactivate voltage-dependent calcium channels
- Modulate inositol phospholipids hydrolysis
Plays a critical role in fine-tuning inhibitory synaptic transmission.
Pre-synaptic GABA-B receptors inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B receptors decrease neuronal excitability by activating inwardly rectifying potassium (Kir) conductance that underlies late inhibitory postsynaptic potentials.
Also implicated in synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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