Thermo Fisher Scientific CD25 Monoclonal Antibody (IL-A111)
소, CD25(IL-2 receptor alpha chain)을 인식하는 마우스 단클론 항체 IL-A111. IHC(F), Flow Cytometry, Immunoprecipitation에 사용 가능. 비결합형 액상 항체로 Protein A 정제, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL-A111 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745295 |
Additional Formats
Product Specific Information
Mouse anti Bovine CD25 antibody, clone IL-A111 recognizes the bovine CD25 cell surface antigen, an approximately 55 kDa glycoprotein also known as Interleukin-2 receptor alpha chain.
Target Information
CD25 (IL2 receptor alpha chain / IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7).
IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG) constitute the high-affinity IL2 receptor.
Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor.
The expression of IL2 in mature thymocytes is monoallelic, representing an unusual regulatory mode for controlling the precise expression of a single gene.
IL2 is primarily produced by mature T cells and plays an important role as a growth factor, differentiation factor, and regulator of cell death.
IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation.
Targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, suggesting a role in the immune response to antigenic stimuli.
Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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