Thermo Fisher Scientific CD25 Monoclonal Antibody (IL-A111)

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: Assay-dependent

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Additional Formats

• FITC
• PE
• Request custom conjugation

Product Specific Information

Mouse anti Bovine CD25 antibody, clone IL-A111 recognizes the bovine CD25 cell surface antigen, an approximately 55 kDa glycoprotein also known as Interleukin-2 receptor alpha chain.

Target Information

CD25 (IL2 receptor alpha chain / IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7).
IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG) constitute the high-affinity IL2 receptor.
Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor.
The expression of IL2 in mature thymocytes is monoallelic, representing an unusual regulatory mode for controlling the precise expression of a single gene.
IL2 is primarily produced by mature T cells and plays an important role as a growth factor, differentiation factor, and regulator of cell death.
IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation.
Targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, suggesting a role in the immune response to antigenic stimuli.
Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.