Thermo Fisher Scientific CD230 (PrP) Monoclonal Antibody (ROS-BH1)
양 프리온 단백질(CD230, PrP)을 인식하는 Thermo Fisher의 ROS-BH1 단클론 항체. Western blot, IHC, Flow cytometry 등 다양한 응용 가능. 단백질 G 정제, 액상 형태, 1 mg/mL 농도. 연구용으로만 사용.
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- Flow Cytometry (Flow): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Sheep |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ROS-BH1 |
| Immunogen | A truncated form of recombinant Ovine PRP spanning residues aa94–aa233 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | <0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745290 |
Product Specific Information
Mouse anti-Sheep CD230 (PrPsc) antibody, clone ROS-BH1 recognizes the prion disease form of prion protein known as CD230.
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associated with lipid raft components and functioning as a signaling molecule.
PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes.
Conversion of normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step triggering the pathogenesis of prion neurodegenerative disorders, such as Creutzfeld-Jakob disease (CJD).
PrPc is rich in alpha-helices, while PrPSc has higher content of beta-sheets and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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