Merck Anti-NFκB p65 Antibody, CT

Anti-NFκB p65 Antibody, CT

from rabbit

Target Information

v-rel reticuloendotheliosis viral oncogene homolog A (avian), v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)), Nuclear factor of kappa light polypeptide gene enhancer

The transcription factor NFκB (Nuclear Factor κB) is involved in the expression and regulation of various important cellular and physiological processes such as:

• Growth and development
• Apoptosis
• Immune and inflammatory responses
• Activation of viral promoters, including human immunodeficiency virus (HIV) long terminal repeats

NFκB represents a group of structurally related and evolutionarily conserved proteins associated with the proto-oncogene c-Rel. There are five members in mammals:

• Rel (cRel)
• RelA (p65)
• RelB
• NFκB1 (p50 and its precursor p105)
• NFκB2 (p52 and its precursor p100)

NFκB/Rel proteins exist as homo- or heterodimers, forming either transcriptionally active or repressive complexes.
While most NFκB dimers activate transcription, p50/50 and p52/52 homodimers can repress target gene transcription.
The p50/p65 heterodimer is the most abundant and transcriptionally active form in cells.

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