Merck Anti-Calbindin D-28K

Anti-Calbindin D-28K

Biological Source

Rabbit

Quality Level

100 (M-Clarity Program)

Antibody Form

Affinity isolated antibody

Antibody Type

Primary antibody

Clone

Polyclonal

Species Reactivity

Mouse, Rat, Human

Packaging

Small pack of 25 μL

Techniques

• Immunocytochemistry: suitable
• Immunohistochemistry (paraffin): suitable
• Western blot: suitable

NCBI Accession Number

NM_004929.2

UniProt Accession Number

P12658

Calbindin (UniProt: P12658; also known as Calbindin D28, D-28K, PCD-29, Spot 35 protein, Vitamin D-dependent calcium-binding protein, avian-type) is encoded by the calb1 gene (gene ID: 12307) in murine species.
Calbindin D-28K is a member of the intracellular calcium-binding protein family related to calmodulin and troponin-C. It possesses four functional calcium-binding sites (aa 24–35, 111–122, 155–166, and 199–210) and six EF-hands, of which one or two are non-functional in metal binding. EF-2 is non-metal binding, and EF-6 has very low Ca²⁺ affinity.
Its biological roles include calcium regulation and signaling, calcium transport and uptake, bone and tooth calcification, and neuronal calcium signaling during development. It also protects neurons from apoptotic cell death.

A decline in Calbindin D-28K levels in hippocampal dentate granule cells correlates with epilepsy models. Calbindin D-28K immunoreactivity is absent in neuronal populations lost early in ALS, and neurons containing this protein are substantially reduced in Huntington’s disease.
(Ref.: Schmidt, H. (2012). Front. Mol. Neurosci. 5:25)

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