Merck Anti-Na+/K+ ATPase α-1 Antibody

Anti-Na+/K+ ATPase α-1 Antibody

Upstate®, from rabbit

생물학적 소스

rabbit

Quality Level

100

항체 형태

purified antibody

antibody product type

primary antibodies

클론

polyclonal

species reactivity

bovine, rat, human

포장

antibody small pack of 25 μg

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

동형

IgG

NCBI 수납 번호

NM_001001586

UniProt 수납 번호

P05023

배송 상태

ambient

Na+/K+ ATPase α-1 is a human gene and functions to maintain Na+ and K+ across the cell membrane which is important for osmoregulation. It is a component of (Na+/K+) ATPase, a transporter that catalyzes the hydrolysis of ATP and transports sodium and potassium ions across the plasma membrane. It also partners with Src and other signaling proteins. Binding of ouabain and other cardiotonic steroids to the (Na+/K+) ATPase activates Src, resulting in the assembly and activation of multiple signaling cascades. Binding of ouabain also induces a positive inotropic effect. Diseases associated with ATPase are Thyrotoxic periodic paralysis and hyperthyroidism. (References: Wikipedia and http://www.bioportfolio.com/gene/476-ATP1A1.html)