Merck Anti-Cytokeratin, pan antibody, Mouse monoclonal

Anti-Cytokeratin, pan antibody, Mouse monoclonal

clone PCK-26, purified from hybridoma cell culture

Anti-Cytokeratin - Monoclonal Anti-Cytokeratin, pan antibody produced in mouse, Anti-Cytokeratin, Monoclonal Anti-pan-Cytokeratin

Quality Level

200

생물학적 소스

mouse

결합

unconjugated

항체 형태

purified from hybridoma cell culture

antibody product type

primary antibodies

클론

PCK-26, monoclonal

form

buffered aqueous solution

species reactivity

pig, human, guinea pig, carp, rabbit, rat, goat, snake, feline, hamster, chicken, mouse, lizard, sheep, canine, bovine

포장

antibody small pack of 25 μL

농도

~1.5 mg/mL

technique(s)

dot blot: suitable
immunocytochemistry: suitable
immunohistochemistry: 10-20 μg/mL using human placenta or skin
western blot: suitable

동형

IgG1

배송 상태

dry ice

저장 온도

−20°C

Monoclonal Anti-Pan Cytokeratin (mouse IgG1 isotype) is derived from the PCK-26 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a cytokeratin preparation from human epidermis. Cytokeratins are a group of at least 29 different proteins. They are characteristic of epithelial and trichocytic cells. Cytokeratin peptide 1 (68 kDa) is expressed together with cytokeratin 10 in the suprabasal cell layers or the differentiation compartment of the epidermis. Its expression increases with epidermal maturation and is modified post translationally in terminally differentiated keratinocytes of the stratum corneum. Cytokeratin peptide 5 (58 kDa) is the primary type II keratin in stratified epithelia, while cytokeratin type 8 (52 kDa) is a major type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a hyperproliferation cytokeratin expressed in tissues with natural or pathological high turnover. Monoclonal antibodies to cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification.