Merck Anti-ZO-1 Antibody

Anti-ZO-1 Antibody

Source: Rabbit
Purification: Affinity chromatography

Target Information

• Protein Name: Tight junction protein 1 (ZO-1, Zonula occludens 1)
• Synonyms: Zona occludens protein 1, Zonula occludens protein 1, Tight junction protein 1

Description

Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membrane-associated guanylate kinase (MAGUK) family and include occludin and zona occludin family members ZO-1, ZO-2, and ZO-3.

These proteins have both structural and signaling roles and are defined by three protein-protein interaction modules:

• PDZ domain
• SH3 domain
• Guanylate kinase (GuK) domain

ZO-1 forms complexes with either ZO-2 or ZO-3. These proteins can also associate with claudin, occludin, and F-actin at tight junction strands, providing a linkage between the actin cytoskeleton and the tight junction.

ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions. Unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.

Specifications