Merck Anti-Tau antibody, Mouse monoclonal

Anti-Tau antibody, Mouse monoclonal

clone Tau46, purified from hybridoma cell culture

Quality Level

200

생물학적 소스

mouse

결합

unconjugated

항체 형태

purified immunoglobulin

antibody product type

primary antibodies

클론

Tau46, monoclonal

form

buffered aqueous solution

species reactivity

bovine, rat, human, mouse

포장

antibody small pack of 25 μL

농도

~2 mg/mL

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.5-1 μg/mL using mouse brain extract

동형

IgG1

UniProt 수납 번호

P10636

배송 상태

dry ice

저장 온도

−20°C

Gene Information

human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)

Tau is a family of microtubule-associated proteins thought to regulate the stability and organization of microtubules in neuronal cells. The tau protein family is derived from alternative mRNA splice variants that originate from a single gene, and result in mature proteins that vary in size from 352 to 441 amino acids (45 to 60 kDa). Tau loses microtubule-binding activity and aggregates into paired helical filaments (PHFs) in neurodegenerative disorders. PHFs are the basic structural components of neurofibrillary tangles (NFTs). NFT accumulation correlates with the clinical progression of Alzheimer′s disease. Phosphorylation can affect the functional properties of tau and hyperphosphorylation of tau may result in the loss of tau′s microtubule binding activity and the formation of the insoluble aggregates. Hyperphosphorylation and nonenzymatic glycosylation are posttranslational modifications detected in PHF-tau, and numerous sites of hyperphosphorylation of both normal and PHF-tau have been identified.