Merck Anti-von Willebrand Factor Antibody
토끼 유래 Anti-von Willebrand Factor 항체로 혈관 내피세포에서 합성되는 vWF 단백질을 인식합니다. 혈소판 부착 및 혈액응고 연구에 적합하며, von Willebrand 질환 관련 연구에 활용 가능합니다.
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Anti-von Willebrand Factor Antibody
Chemicon®, from Rabbit
Factor VIII Related Antigen
von Willebrand factor (UniProt: P04275; also known as vWF) is encoded by the VWF (also known as F8VWF) gene (Gene ID: 7450) in humans. vWF is a multimeric plasma glycoprotein synthesized by endothelial cells and plays an important role in maintaining hemostasis.
It is synthesized with a signal peptide (aa 1–22), which is cleaved off in the mature form. vWF promotes platelet adhesion at sites of vascular injury by forming a molecular bridge between the sub-endothelial collagen matrix and the platelet-surface receptor complex GPIb-IX-V.
Additionally, vWF acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure, and protecting it from premature clearance from plasma.
Mutations in the VWF gene are linked to von Willebrand diseases types 1–3, which are common hemorrhagic disorders caused by impaired platelet aggregation. Two isoforms of vWF have been described, produced by alternative splicing.
제품 사양
| 항목 | 내용 |
|---|---|
| 제품명 | Anti-von Willebrand Factor Antibody |
| 브랜드 | Chemicon® |
| 공급업체 | Merck Sigma |
| 숙주 | Rabbit |
| 인식 대상 | von Willebrand Factor (vWF) |
| 유전자 ID | 7450 |
| UniProt ID | P04275 |
| 관련 질환 | von Willebrand Disease (Type 1–3) |
| 주요 기능 | 혈소판 부착 촉진, Factor VIII 안정화 |
| 적용 분야 | 혈액응고, 내피세포 연구, 단백질 상호작용 연구 |
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