Merck R spondin-1 human

R spondin-1 human

recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE)

R-spondin-1, RSPO-1, Rspondin-1, CRISTIN-3, CRISTIN3, Rspondin, RP11-566C13.1, FLJ40906, RSPO1, RSPO

생물학적 소스

human

재조합

expressed in HEK 293 cells

태그

6-His tagged (C-terminus)

assay

≥98% (SDS-PAGE)

form

lyophilized

분자량

calculated mol wt 27.6 kDa
observed mol wt 40 kDa by SDS-PAGE (reducing) (Ser 21 is the predicted N-terminal .)

포장

pkg of 10 μg

불순물

<1 EU/μg endotoxin (LAL test)

UniProt 수납 번호

Q2MKA7

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... RSPO1(284654)

R-spondin-1, also known as Roof plate-specific Spondin 1 (RSPO1) and cysteine rich and single thrombospondin domain containing protein 3 (Cristin 3), is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. All R spondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteine rich furin like domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furin like domains are needed for β-catenin stabilization. A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus. Potential isoforms of 200 and 236 aa have an alternate, shorter N-terminus or are missing aa 146-208, respectively.