Merck PDGF-CC human

PDGF-CC human

Recombinant human Platelet-Derived Growth Factor-CC (PDGF-CC)

제품 특징

• Recombinant protein expressed in E. coli
• ≥98% purity (SDS-PAGE, HPLC)
• Suitable for cell culture applications
• Lyophilized form, white to off-white powder
• Endotoxin level <0.1 EU/μg (tested)

제품 정보

제품 설명

The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members: PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC, and PDGF-DD.
The mature and active form of these proteins is an anti-parallel disulfide-linked dimer of two 12–14 kDa polypeptide chains, obtained through proteolytic processing of inactive precursor proteins containing an N-terminal CUB domain and a PDGF/VEGF homologous domain.

PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and act as potent mitogens for various cell types, including smooth muscle, connective tissue, bone, cartilage, and certain tumor cells.
They play important roles in biological processes such as hyperplasia, chemotaxis, embryonic neuron development, and epithelial cell development of respiratory tubules.

Mature PDGFs are stored in platelet α-granules and released upon platelet activation.
PDGF-AA, -AB, -BB, and –CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor.
Recombinant human PDGF-CC is a 25 kDa protein consisting of two identical disulfide-linked 112 amino acid polypeptide chains.