Thermo Fisher Scientific Fibronectin Polyclonal Antibody
Fibronectin 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. Human, Mouse, Rat에 반응하며, 고순도(>95%)로 정제되었습니다. PBS/glycerol buffer에 보관되며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 2331–2380 of Human Fibronectin 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2803101 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers.
It is abundant during embryonic development and tissue remodeling, and also exists as a soluble plasma protein.
Fibronectin contains repeating modules forming domains that interact with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell surface receptors (e.g., integrins).
It plays a key role in cell adhesion, migration, wound healing, blood coagulation, host defense, and metastasis.
Fibronectin expression is elevated in non-small cell lung carcinoma, enhancing tumorigenicity and resistance to apoptosis.
The gene encoding fibronectin undergoes alternative splicing, producing up to 20 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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