Thermo Fisher Scientific D-Amino Acid Oxidase Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Store vial at 4°C prior to restoration. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

Anti-D-Amino Acid Oxidase is an IgG fraction antibody purified from monospecific antiserum by a multi-step process including delipidation, salt fractionation, and ion-exchange chromatography, followed by extensive dialysis against the buffer stated above. Immunoelectrophoresis assay resulted in a single precipitin arc against anti-Sheep Serum as well as purified and partially purified D-Amino Acid Oxidase (Pig Kidney). Cross-reactivity against D-Amino Acid Oxidase from other tissues and species may occur but has not been specifically determined.

Target Information

This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein that uses flavin adenine dinucleotide (FAD) as its prosthetic group. It acts on a wide variety of D-amino acids but is inactive on naturally occurring L-amino acids. Its biological function may involve detoxification of D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor, and may play a role in the pathophysiology of schizophrenia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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