Thermo Fisher Scientific GNAI3 Polyclonal Antibody
GNAI3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot과 ELISA에 적합하며, 고순도 Affinity Chromatography 정제 제품입니다. PBS/glycerol buffer에 보관하며 -20°C에서 안정적입니다.
- 카탈로그번호
- PA5120385
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 1–100 of human GNAI3 (NP_006487.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.86 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913957 |
Product Specific Information
- Positive test controls: LO2, HepG2, Mouse kidney, Mouse brain, Rat kidney
- Target localization: Cell membrane, Cytoplasm, Lipid-anchor, Membrane, Centrosome, Cytoskeleton, Microtubule organizing center
Immunogen sequence:
MGCTLSAEDK AAVERSKMID RNLREDGEKA AKEVKLLLLG AGESGKSTIV KQMKIIHEDG YSEDECKQYK VVVYSNTIQS IIAIIRAMGR LKIDFGEAAR
Target Information
Heterotrimeric G proteins relay signals from cell surface receptors to intracellular effectors. Each receptor detects specific extracellular stimuli such as photons, pheromones, odorants, hormones, or neurotransmitters, while effectors like adenyl cyclase generate intracellular messengers.
In mammals, G protein alpha, beta, and gamma subunits are encoded by at least 16, 4, and 7 genes respectively. The alpha subunits bind and hydrolyze GTP and regulate effector activity.
Four major classes of Galpha subunits exist: Gs, Gi, Gq, and Galpha 12/13. The Gi class includes Galpha i-1, Galpha i-2, Galpha i-3, Galpha o, Galpha t1, Galpha t2, Galpha z, and Galpha gust, which are susceptible to pertussis toxin modification. The three Galpha i subtypes function to open atrial potassium channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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