Thermo Fisher Scientific GNAI3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Positive test controls: LO2, HepG2, Mouse kidney, Mouse brain, Rat kidney
• Target localization: Cell membrane, Cytoplasm, Lipid-anchor, Membrane, Centrosome, Cytoskeleton, Microtubule organizing center

Immunogen sequence:
MGCTLSAEDK AAVERSKMID RNLREDGEKA AKEVKLLLLG AGESGKSTIV KQMKIIHEDG YSEDECKQYK VVVYSNTIQS IIAIIRAMGR LKIDFGEAAR

Target Information

Heterotrimeric G proteins relay signals from cell surface receptors to intracellular effectors. Each receptor detects specific extracellular stimuli such as photons, pheromones, odorants, hormones, or neurotransmitters, while effectors like adenyl cyclase generate intracellular messengers.
In mammals, G protein alpha, beta, and gamma subunits are encoded by at least 16, 4, and 7 genes respectively. The alpha subunits bind and hydrolyze GTP and regulate effector activity.
Four major classes of Galpha subunits exist: Gs, Gi, Gq, and Galpha 12/13. The Gi class includes Galpha i-1, Galpha i-2, Galpha i-3, Galpha o, Galpha t1, Galpha t2, Galpha z, and Galpha gust, which are susceptible to pertussis toxin modification. The three Galpha i subtypes function to open atrial potassium channels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.