Thermo Fisher Scientific TNFRSF10A Monoclonal Antibody (OTI11B12), TrueMAB
Human TNFRSF10A 단백질(aa 263-468)에 특이적인 Mouse monoclonal antibody. Western blot에서 1:2,000 희석으로 검증됨. Lyophilized 형태로 제공되며, PBS와 trehalose buffer에 보관. 세포사멸 및 NF-kB 활성화 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI11B12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 263–468 of human TNFRSF10A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve a final concentration of approximately 1 mg/mL.
- For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also known as TRAIL receptor 1. Its ligand, TRAIL, belongs to the TNF family. DR4 mediates apoptosis and NF-κB activation in various cells and tissues. Apoptosis, a programmed cell death process, plays a crucial role in normal cellular differentiation and development. It is induced by interactions between cytokines (e.g., TNF, Fas ligand) and their death domain-containing receptors (e.g., TNFR1, Fas receptor).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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