Thermo Fisher Scientific Calnexin Monoclonal Antibody (AF18), Alexa Fluor 647

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1–10 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: Not specified
• Publications: 1 available

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Alexa Fluor 555
• Request custom conjugation

Product Specific Information

MA3027A647 detects calnexin from human and mouse tissues.
The MA3027A647 antigen is Focus human hepatoma cell lysate.

Target Information

Calnexin (also known as IP90, p88, and p90) is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER). It acts as a molecular chaperone, assisting in the proper folding and assembly of polypeptides into multisubunit proteins.
Calnexin associates with MHC class I heavy chains and partial complexes of the T cell receptor and B cell membrane immunoglobulin but not with completed receptor complexes.
It retains incompletely or improperly folded proteins within the ER.
Soluble ER resident proteins often contain the KDEL sequence for retention, while integral membrane ER proteins like calnexin lack KDEL but have positively charged cytosolic residues ensuring ER localization.
Calnexin consists of a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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