Thermo Fisher Scientific ITIH1 (Cleaved Asp672) Polyclonal Antibody
Human, Mouse, Rat 반응성의 Rabbit Polyclonal Antibody로 Western blot에 적합. Cleaved Asp672 부위 인식하며 71/101 kDa 단백질 검출. 고순도(>95%) 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 650–700 of human ITI-H1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2554056 |
Product Specific Information
This antibody detects endogenous ITIH1 protein at molecular weights of 71 kDa and 101 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The inter-alpha trypsin inhibitor (ITI) family comprises plasma serine protease inhibitors synthesized in the liver, formed from combinations of heavy chains (ITI-H1, ITI-H2, ITI-H3) and a light chain (Bikunin).
ITI-H4 includes a Pro-rich region at its C-terminus. ITI is a glycoprotein composed of two heavy chains (ITI-H1, ITI-H2) and Bikunin linked by chondroitin sulfate.
Bikunin confers protease inhibitor function, while heavy chains (SHAPs) bind to hyaluronic acid (HA) for matrix stabilization.
ITI-H1 may stimulate phagocytotic cells and is associated with both antitumoral properties and malignant transformation of lung tissue.
ITI-H1 and ITI-H2 are linked to calcium oxalate stone formation in kidney and urine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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