Thermo Fisher Scientific NOTCH2 (Cleaved Ala1734) Polyclonal Antibody
NOTCH2 단백질의 절단형(Ala1734)을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 사람, 생쥐, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 세포 발달 및 분화 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1734–1800 of human Notch2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2554057 |
Product Specific Information
This antibody detects endogenous NOTCH2 protein at molecular weights of approximately 85 and 110 kDa.
Purity is greater than 95% by SDS-PAGE.
Target Information
The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate decisions. Four Notch homologs have been identified in mammals (Notch1–4), expressed in various tissues during both embryonic and adult stages. These genes are involved in multiple signaling pathways and are often overexpressed or rearranged in human tumors.
Ligands for Notch include Jagged, Jagged2, and Delta. Jagged activates Notch signaling and inhibits myoblast differentiation by suppressing muscle gene expression. Jagged2 is implicated in epithelial-mesenchymal interaction–dependent tissue development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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