Thermo Fisher Scientific VDAC Monoclonal Antibody (N152B/23), APC

Thermo Fisher Scientific VDAC Monoclonal Antibody (N152B/23), APC

Applications and Tested Dilution

• Western Blot (WB): 1:1,000
• Immunohistochemistry (IHC): Assay-dependent
• Immunocytochemistry (ICC/IF): Assay-dependent

Product Specifications

Additional Formats

• FITC (MA5-45667)
• PerCP (MA5-45668)
• Custom conjugation available upon request

Product Specific Information

• Mouse: 98% identity (279/283 amino acids identical)
• Rat: 98% identity (279/283 amino acids identical)

• 60% identity with VDAC2 and VDAC3

• Detects approximately 30 kDa
• Does not cross-react with VDAC2 or VDAC3 (KO validation results)
• 1 µg/mL sufficient for detection of VDAC1 in 20 µg of rat brain lysate by colorimetric immunoblot using Goat anti-mouse IgG:HRP
• Formerly sold as clone S152B-23

Target Information

Voltage-dependent anion channel (VDAC) proteins are abundant pore-forming proteins located in the eukaryotic mitochondrial outer membrane and also expressed in the plasma membrane.
They play essential roles in cellular metabolism and apoptosis regulation, mediating metabolite exchange (ADP/ATP, succinate, citrate) between cytosol and mitochondria.
VDAC1 in the plasma membrane contributes to apoptosis regulation through its redox activity.

Usage

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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