Thermo Fisher Scientific Tau protein Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker protein between both. Axonal polarity is influenced by TAU/MAPT localization in the neuronal cell body domain defined by the centrosome.

Short isoforms of Tau contribute to cytoskeletal plasticity, while longer isoforms support stabilization. In its hyper-phosphorylated form, Tau forms paired helical filaments (PHF), the main component of neurofibrillary lesions in Alzheimer’s disease (AD). Hyper-phosphorylation disrupts microtubule binding, leading to neuronal degeneration in AD. Tau is phosphorylated by various kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also associated with other CNS disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.