Thermo Fisher Scientific MIP-3 beta Polyclonal Antibody
Thermo Fisher Scientific의 MIP-3 beta Polyclonal Antibody는 마우스 CCL19/MIP-3 beta를 타겟으로 하는 염소 유래 IgG 항체로, WB, ICC/IF, 중화 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 및 trehalose 버퍼에 보존됩니다.
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- PA547958
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–15 µg/mL |
| Neutralization (Neu) | 0.8–4 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant mouse CCL19/MIP-3 beta (Gly26–Val107, Ser108LeuGlu) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610118 |
Product Specific Information
- In direct ELISAs, less than 30% cross-reactivity with recombinant rat CCL19/MIP-3 beta is observed.
- Less than 10% cross-reactivity with recombinant human CCL19/MIP-3 beta is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level: <0.01 EU per 1 µg of antibody (LAL method).
Target Information
CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is most closely related to CCL21, sharing 32% amino acid sequence homology.
CCL19 and CCL21 are mainly expressed by stromal cells in the T cell-rich zones of lymph nodes and are critical mediators of homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs.
They play roles in T cell priming, activation, and recruitment of lymphocytes to inflamed tissue.
Both proteins signal via the G protein-coupled receptor CCR7, expressed on T cells and mature dendritic cells. Although both exhibit the same affinity for CCR7, only CCL19 binding results in desensitization and internalization of the receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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